Campus Chicago Address 676 N St Clair St Suite 1400 CH S208 Telephone +1 312 503 1901 Email

Academic Title Associate Professor Primary Department Department of Medicine, Gastroenterology Division, Feinberg School of Medicine Center Affiliations Cancer Prevention GI Oncology

Publications (30)

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Publications
Bonertz, A.; Weitz, J.; Pietsch, D. H.; Rahbari, N. N.; Schlude, C.; Ge, Y.; Juenger, S.; Vlodavsky, I.; Khazaie, K; Jaeger, D.; Reissfelder, C.; Antolovic, D.; Aigner, M.; Koch, M.; Beckhove, P. Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma. J Clin Invest (2009) 119:3311-3321.
Brown, J. B.; Lee, G.; Managlia, E.; Grimm, G. R.; Dirisina, R.; Goretsky, T.; Cheresh, P.; Blatner, N. R.; Khazaie, K; Yang, G; Li, L; Barrett, TA 5-ASA inhibits epithelial beta-catenin activation in chronic ulcerative colitis. Gastroenterology (2009) In process.
Gounaris, E.; Blatner, N. R.; Dennis, K.; Magnusson, F.; Gurish, M. F.; Strom, T. B.; Beckhove, P.; Gounari, F.; Khazaie, K T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis. Cancer Res (2009) 69:5490-5497.
Khazaie, K; Bonertz, A.; Beckhove, P. Current developments with peptide-based human tumor vaccines. Curr Opin Oncol (2009) 21:524-530.
Maltby, S.; Khazaie, K; McNagny, K. M. Mast cells in tumor growth: Angiogenesis, tissue remodelling and immune-modulation. Biochim Biophys Acta (2009) 1796:19-26.
Gounaris, E.; Tung, C. H.; Restaino, C.; Maehr, R.; Kohler, R.; Joyce, J. A.; Ploegh, H. L.; Barrett, TA; Weissleder, R.; Khazaie, K Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS One (2008) 3:e2916.
Ha, S. D.; Martins, A.; Khazaie, K; Han, J.; Chan, B. M.; Kim, S. O. Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages. J Immunol (2008) 181:690-697.
Li, X.; Gounari, F.; Protopopov, A.; Khazaie, K; von Boehmer, H. Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1. J Exp Med (2008) 205:2851-2861.
Magnusson, F. C.; Liblau, R. S.; von Boehmer, H.; Pittet, M. J.; Lee, J. W.; Turley, S. J.; Khazaie, K Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity. Gastroenterology (2008) 134:1028-1037.
Gounaris, E.; Erdman, S. E.; Restaino, C.; Gurish, M. F.; Friend, D. S.; Gounari, F.; Lee, D. M.; Zhang, G.; Glickman, J. N.; Shin, K.; Rao, V. P.; Poutahidis, T.; Weissleder, R.; McNagny, K. M.; Khazaie, K Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A (2007) 104:19977-19982.
Guo, Z.; Dose, M.; Kovalovsky, D.; Chang, R.; O'Neil, J.; Look, A. T.; von Boehmer, H.; Khazaie, K; Gounari, F. Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. Blood (2007) 109:5463-5472.
Cabarrocas, J.; Cassan, C.; Magnusson, F.; Piaggio, E.; Mars, L.; Derbinski, J.; Kyewski, B.; Gross, D. A.; Salomon, B. L.; Khazaie, K; Saoudi, A.; Liblau, R. S. Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage. Proc Natl Acad Sci U S A (2006) 103:8453-8458.
Dose, M.; Khan, I.; Guo, Z.; Kovalovsky, D.; Krueger, A.; von Boehmer, H.; Khazaie, K; Gounari, F. c-Myc mediates pre-TCR-induced proliferation but not developmental progression. Blood (2006) 108:2669-2677.
Khazaie, K; von Boehmer, H. The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer. Semin Cancer Biol (2006) 16:124-136.
Kretschmer, K.; Apostolou, I.; Jaeckel, E.; Khazaie, K; von Boehmer, H. Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer. Immunol Rev (2006) 212:163-169.
Mempel, T. R.; Pittet, M. J.; Khazaie, K; Weninger, W.; Weissleder, R.; von Boehmer, H.; von Andrian, U. H. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity (2006) 25:129-141.
Bridger, J. M.; Kalla, C.; Wodrich, H.; Weitz, S.; King, J. A.; Khazaie, K; Krausslich, H. G.; Lichter, P. Nuclear RNAs confined to a reticular compartment between chromosome territories. Exp Cell Res (2005) 302:180-193.
Chen, M. L.; Pittet, M. J.; Gorelik, L.; Flavell, R. A.; Weissleder, R.; von Boehmer, H.; Khazaie, K Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A (2005) 102:419-424.
Chen, W. T.; Khazaie, K; Zhang, G.; Weissleder, R.; Tung, C. H. Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probe. Mol Imaging (2005) 4:67-74.
Gounari, F.; Chang, R.; Cowan, J.; Guo, Z.; Dose, M.; Gounaris, E.; Khazaie, K Loss of adenomatous polyposis coli gene function disrupts thymic development. Nat Immunol (2005) 6:800-809.

The above publications are sorted by year, faculty last name, and first author. Click on any highlighted author listed to find all publications attributed to that individual. Click on the publication title to see the abstract. First authors who are faculty are highlighted like this. Last authors who are faculty are highlighted like this. Other authors who are faculty are highlighted like this.

Terrence Barrett
Guang-Yu Yang
Liming Li