Bioactive Nortriterpenoids from Schisandra grandiflora.
Journal of natural products
(2009)
72:1678-1681.
Abstract
Three new nortriterpenoids, schigrandilactones A-C (1-3), along with eight known compounds, were isolated from an organic solvent extract of Schisandra grandiflora. Compounds 1 and 2 feature a spirocyclic moiety in their structures, and compound 3 was characterized with a new oxygenated pattern. The relative configurations of 1 and 3 were determined through single-crystal X-ray experiments. In addition, compounds 1 and 2 displayed cytotoxic activity against two human cancer cell lines, and compound 3 showed anti-HIV-1 inhibition in infected C8166 cells.
Three new nortriterpenoids, schigrandilactones A-C (1-3), along with eight known compounds, were isolated from an organic solvent extract of Schisandra grandiflora. Compounds 1 and 2 feature a spirocyclic moiety in their structures, and compound 3 was characterized with a new oxygenated pattern. The relative configurations of 1 and 3 were determined through single-crystal X-ray experiments. In addition, compounds 1 and 2 displayed cytotoxic activity against two human cancer cell lines, and compound 3 showed anti-HIV-1 inhibition in infected C8166 cells.
MeSH terms
Anti-HIV Agents chemistry isolation & purification pharmacology X-Ray Crystallography Antitumor Drug Screening Assays Chinese Herbal Drugs HIV-1 drug effects Molecular Conformation Molecular Structure Schisandra Tibet Triterpenes
Anti-HIV Agents chemistry isolation & purification pharmacology X-Ray Crystallography Antitumor Drug Screening Assays Chinese Herbal Drugs HIV-1 drug effects Molecular Conformation Molecular Structure Schisandra Tibet Triterpenes
Note
Automated medline import. Electronic deposit: .Electronic publication: 2009-08-19. Publication Date: 2009-09-01. Publication status: ppublish. Status: MEDLINE.
Automated medline import. Electronic deposit: .Electronic publication: 2009-08-19. Publication Date: 2009-09-01. Publication status: ppublish. Status: MEDLINE.