EndNote Reference

%0 Journal Article
%A Paunesku, T.
%A Zhang, Y.
%A Gemmell, M. A.
%A Woloschak, G. E.
%D 2000
%T p53 gene deletions in paraffin-preserved lymphoid tumors from irradiated mice.
%J Leuk Res
%V 24
%N 6
%P 511-517
%M 10781686
%U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10781686
%X Experiments were performed to measure deletions in the p53 gene in paraffin-embedded tissues (tumors and control) derived from mice exposed to gamma-rays or neutrons up to 28 years ago. Deletions in exons 1, 3, 4, 5, 6, 7 and 9 were monitored by PCR and Southern blotting techniques. The results of these experiments demonstrated p53 deletions in only 1/6 spontaneous tumors but in 5/6 gamma-ray-induced and 5/6 neutron-induced tumors. Exons deleted in tumors from gamma-ray exposed mice were similar to those deleted in tumors from neutron-exposed mice. They document differences in spectra of p53 deletions in comparing spontaneous radiation-induced tumors.
%K Animals
%K Blotting, Southern
%K Exons
%K *Gene Deletion
%K Lymphoma/*genetics
%K Mice
%K Mice, Inbred BALB C
%K Mice, Inbred C57BL
%K Paraffin
%K Polymerase Chain Reaction
%K Tumor Suppressor Protein p53/*genetics
%+ Biosciences Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439-4833, USA.